Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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SMCL Lung Bhattacharjee Cluster Number 35 (141 genes) This page contains all miRNA mediated regulation and functional enrichment for SMCL Lung Bhattacharjee cluster number 35. Information about lung cancer can be found on Wikipedia, and further information about the "SMCL Lung Bhattacharjee" dataset can be found in Bhattacharjee et al., 2001. Inferred miRNA Mediated Regulation Weeder-miRvestigator PITA TargetScan zzz999 zzz999 hsa-mir-212 Gene Ontology Enrichment GO ID GO Term Annotated Genes in Cluster GO:0000070 mitotic sister chromatid segregation 4 GO:0000075 cell cycle checkpoint 15 GO:0000085 G2 phase of mitotic cell cycle 4 GO:0000086 G2/M transition of mitotic cell cycle 12 GO:0000087 M phase of mitotic cell cycle 25 GO:0000212 meiotic spindle organization 2 GO:0000226 microtubule cytoskeleton organization 13 GO:0000236 mitotic prometaphase 10 GO:0000278 mitotic cell cycle 39 GO:0000279 M phase 33 GO:0000280 nuclear division 25 GO:0000375 RNA splicing, via transesterification reactions 10 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 GO:0000398 nuclear mRNA splicing, via spliceosome 9 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 73 GO:0006259 DNA metabolic process 21 GO:0006281 DNA repair 12 GO:0006310 DNA recombination 8 GO:0006350 transcription, DNA-dependent 46 GO:0006366 transcription from RNA polymerase II promoter 23 GO:0006396 RNA processing 18 GO:0006397 mRNA processing 13 GO:0006403 RNA localization 8 GO:0006405 RNA export from nucleus 5 GO:0006458 'de novo' protein folding 5 GO:0006974 response to DNA damage stimulus 19 GO:0006996 organelle organization 42 GO:0007017 microtubule-based process 19 GO:0007049 cell cycle 47 GO:0007051 spindle organization 10 GO:0007059 chromosome segregation 8 GO:0007067 mitosis 25 GO:0007093 mitotic cell cycle checkpoint 10 GO:0007094 mitotic cell cycle spindle assembly checkpoint 5 GO:0007126 meiosis 7 GO:0007346 regulation of mitotic cell cycle 15 GO:0008152 metabolic process 113 GO:0008380 RNA splicing 13 GO:0009059 macromolecule biosynthetic process 56 GO:0009987 cellular process 135 GO:0010467 gene expression 61 GO:0010498 proteasomal protein catabolic process 9 GO:0010564 regulation of cell cycle process 21 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport 8 GO:0016043 cellular component organization 62 GO:0016070 RNA metabolic process 47 GO:0016071 mRNA metabolic process 14 GO:0019058 viral infectious cycle 9 GO:0022402 cell cycle process 44 GO:0022403 cell cycle phase 43 GO:0022613 ribonucleoprotein complex biogenesis 9 GO:0022900 electron transport chain 7 GO:0022904 respiratory electron transport chain 6 GO:0031018 endocrine pancreas development 6 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 8 GO:0031577 spindle checkpoint 6 GO:0033554 cellular response to stress 23 GO:0034621 cellular macromolecular complex subunit organization 22 GO:0034622 cellular macromolecular complex assembly 14 GO:0034645 cellular macromolecule biosynthetic process 56 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 9 GO:0043170 macromolecule metabolic process 95 GO:0043933 macromolecular complex subunit organization 26 GO:0044237 cellular metabolic process 111 GO:0044238 primary metabolic process 106 GO:0044260 cellular macromolecule metabolic process 93 GO:0048285 organelle fission 25 GO:0050657 nucleic acid transport 8 GO:0050658 RNA transport 8 GO:0051028 mRNA transport 7 GO:0051084 'de novo' posttranslational protein folding 5 GO:0051236 establishment of RNA localization 8 GO:0051276 chromosome organization 20 GO:0051301 cell division 27 GO:0051319 G2 phase 4 GO:0051321 meiotic cell cycle 8 GO:0051325 interphase 22 GO:0051327 M phase of meiotic cell cycle 7 GO:0051329 interphase of mitotic cell cycle 21 GO:0051340 regulation of ligase activity 6 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 5 GO:0051438 regulation of ubiquitin-protein ligase activity 6 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 6 GO:0051726 regulation of cell cycle 25 GO:0051983 regulation of chromosome segregation 3 GO:0065003 macromolecular complex assembly 19 GO:0065004 protein-DNA complex assembly 6 Overlap Between miRNA Target Genes and Enriched Gene Ontology Annotations miRNA Method GO ID GO Term Overlap GO Annotated Genes Cluster Size miRNA Targets Genes P-Value hsa-mir-212 TargetScan GO:0000070 mitotic sister chromatid segregation 1 4 141 18 0.07931619 hsa-mir-212 TargetScan GO:0000075 cell cycle checkpoint 2 15 141 18 0.2944661 hsa-mir-212 TargetScan GO:0000085 G2 phase of mitotic cell cycle 0 4 141 18 0.4245726 hsa-mir-212 TargetScan GO:0000086 G2/M transition of mitotic cell cycle 1 12 141 18 0.4712139 hsa-mir-212 TargetScan GO:0000087 M phase of mitotic cell cycle 2 25 141 18 0.6586976 hsa-mir-212 TargetScan GO:0000212 meiotic spindle organization 0 2 141 18 0.2398176 hsa-mir-212 TargetScan GO:0000226 microtubule cytoskeleton organization 1 13 141 18 0.517104 hsa-mir-212 TargetScan GO:0000236 mitotic prometaphase 1 10 141 18 0.3734079 hsa-mir-212 TargetScan GO:0000278 mitotic cell cycle 2 39 141 18 0.9252316 hsa-mir-212 TargetScan GO:0000279 M phase 2 33 141 18 0.8469494 hsa-mir-212 TargetScan GO:0000280 nuclear division 2 25 141 18 0.6586976 hsa-mir-212 TargetScan GO:0000375 RNA splicing, via transesterification reactions 3 10 141 18 0.02434688 hsa-mir-212 TargetScan GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3 9 141 18 0.01592309 hsa-mir-212 TargetScan GO:0000398 nuclear mRNA splicing, via spliceosome 3 9 141 18 0.01592309 hsa-mir-212 TargetScan GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9 73 141 18 0.4646513 hsa-mir-212 TargetScan GO:0006259 DNA metabolic process 2 21 141 18 0.5249946 hsa-mir-212 TargetScan GO:0006281 DNA repair 0 12 141 18 0.8194389 hsa-mir-212 TargetScan GO:0006310 DNA recombination 0 8 141 18 0.6746391 hsa-mir-212 TargetScan GO:0006350 transcription, DNA-dependent 4 46 141 18 0.7660151 hsa-mir-212 TargetScan GO:0006366 transcription from RNA polymerase II promoter 1 23 141 18 0.8362192 hsa-mir-212 TargetScan GO:0006396 RNA processing 5 18 141 18 0.01324579 hsa-mir-212 TargetScan GO:0006397 mRNA processing 4 13 141 18 0.01301446 hsa-mir-212 TargetScan GO:0006403 RNA localization 2 8 141 18 0.06534269 hsa-mir-212 TargetScan GO:0006405 RNA export from nucleus 1 5 141 18 0.1221582 hsa-mir-212 TargetScan GO:0006458 'de novo' protein folding 0 5 141 18 0.5001762 hsa-mir-212 TargetScan GO:0006974 response to DNA damage stimulus 1 19 141 18 0.738798 hsa-mir-212 TargetScan GO:0006996 organelle organization 5 42 141 18 0.4584614 hsa-mir-212 TargetScan GO:0007017 microtubule-based process 1 19 141 18 0.738798 hsa-mir-212 TargetScan GO:0007049 cell cycle 2 47 141 18 0.9752515 hsa-mir-212 TargetScan GO:0007051 spindle organization 1 10 141 18 0.3734079 hsa-mir-212 TargetScan GO:0007059 chromosome segregation 1 8 141 18 0.2707429 hsa-mir-212 TargetScan GO:0007067 mitosis 2 25 141 18 0.6586976 hsa-mir-212 TargetScan GO:0007093 mitotic cell cycle checkpoint 2 10 141 18 0.118212 hsa-mir-212 TargetScan GO:0007094 mitotic cell cycle spindle assembly checkpoint 0 5 141 18 0.5001762 hsa-mir-212 TargetScan GO:0007126 meiosis 0 7 141 18 0.6241521 hsa-mir-212 TargetScan GO:0007346 regulation of mitotic cell cycle 2 15 141 18 0.2944661 hsa-mir-212 TargetScan GO:0008152 metabolic process 14 113 141 18 0.5009884 hsa-mir-212 TargetScan GO:0008380 RNA splicing 5 13 141 18 0.001851625 hsa-mir-212 TargetScan GO:0009059 macromolecule biosynthetic process 8 56 141 18 0.2412061 hsa-mir-212 TargetScan GO:0009987 cellular process 17 135 141 18 0.4336706 hsa-mir-212 TargetScan GO:0010467 gene expression 7 61 141 18 0.5545493 hsa-mir-212 TargetScan GO:0010498 proteasomal protein catabolic process 0 9 141 18 0.7186729 hsa-mir-212 TargetScan GO:0010564 regulation of cell cycle process 2 21 141 18 0.5249946 hsa-mir-212 TargetScan GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport 2 8 141 18 0.06534269 hsa-mir-212 TargetScan GO:0016043 cellular component organization 7 62 141 18 0.5802994 hsa-mir-212 TargetScan GO:0016070 RNA metabolic process 6 47 141 18 0.3867798 hsa-mir-212 TargetScan GO:0016071 mRNA metabolic process 4 14 141 18 0.01858619 hsa-mir-212 TargetScan GO:0019058 viral infectious cycle 0 9 141 18 0.7186729 hsa-mir-212 TargetScan GO:0022402 cell cycle process 2 44 141 18 0.9617636 hsa-mir-212 TargetScan GO:0022403 cell cycle phase 2 43 141 18 0.9560388 hsa-mir-212 TargetScan GO:0022613 ribonucleoprotein complex biogenesis 2 9 141 18 0.09005249 hsa-mir-212 TargetScan GO:0022900 electron transport chain 2 7 141 18 0.04445453 hsa-mir-212 TargetScan GO:0022904 respiratory electron transport chain 2 6 141 18 0.02765373 hsa-mir-212 TargetScan GO:0031018 endocrine pancreas development 0 6 141 18 0.5663294 hsa-mir-212 TargetScan GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 0 8 141 18 0.6746391 hsa-mir-212 TargetScan GO:0031577 spindle checkpoint 0 6 141 18 0.5663294 hsa-mir-212 TargetScan GO:0033554 cellular response to stress 1 23 141 18 0.8362192 hsa-mir-212 TargetScan GO:0034621 cellular macromolecular complex subunit organization 2 22 141 18 0.5606063 hsa-mir-212 TargetScan GO:0034622 cellular macromolecular complex assembly 2 14 141 18 0.2561039 hsa-mir-212 TargetScan GO:0034645 cellular macromolecule biosynthetic process 8 56 141 18 0.2412061 hsa-mir-212 TargetScan GO:0043161 proteasomal ubiquitin-dependent protein catabolic process 0 9 141 18 0.7186729 hsa-mir-212 TargetScan GO:0043170 macromolecule metabolic process 10 95 141 18 0.8109412 hsa-mir-212 TargetScan GO:0043933 macromolecular complex subunit organization 3 26 141 18 0.4328475 hsa-mir-212 TargetScan GO:0044237 cellular metabolic process 14 111 141 18 0.4372707 hsa-mir-212 TargetScan GO:0044238 primary metabolic process 11 106 141 18 0.8804499 hsa-mir-212 TargetScan GO:0044260 cellular macromolecule metabolic process 10 93 141 18 0.7702976 hsa-mir-212 TargetScan GO:0048285 organelle fission 2 25 141 18 0.6586976 hsa-mir-212 TargetScan GO:0050657 nucleic acid transport 2 8 141 18 0.06534269 hsa-mir-212 TargetScan GO:0050658 RNA transport 2 8 141 18 0.06534269 hsa-mir-212 TargetScan GO:0051028 mRNA transport 2 7 141 18 0.04445453 hsa-mir-212 TargetScan GO:0051084 'de novo' posttranslational protein folding 0 5 141 18 0.5001762 hsa-mir-212 TargetScan GO:0051236 establishment of RNA localization 2 8 141 18 0.06534269 hsa-mir-212 TargetScan GO:0051276 chromosome organization 4 20 141 18 0.08570806 hsa-mir-212 TargetScan GO:0051301 cell division 2 27 141 18 0.7159073 hsa-mir-212 TargetScan GO:0051319 G2 phase 0 4 141 18 0.4245726 hsa-mir-212 TargetScan GO:0051321 meiotic cell cycle 0 8 141 18 0.6746391 hsa-mir-212 TargetScan GO:0051325 interphase 1 22 141 18 0.8152299 hsa-mir-212 TargetScan GO:0051327 M phase of meiotic cell cycle 0 7 141 18 0.6241521 hsa-mir-212 TargetScan GO:0051329 interphase of mitotic cell cycle 1 21 141 18 0.7920823 hsa-mir-212 TargetScan GO:0051340 regulation of ligase activity 0 6 141 18 0.5663294 hsa-mir-212 TargetScan GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 0 5 141 18 0.5001762 hsa-mir-212 TargetScan GO:0051438 regulation of ubiquitin-protein ligase activity 0 6 141 18 0.5663294 hsa-mir-212 TargetScan GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 0 6 141 18 0.5663294 hsa-mir-212 TargetScan GO:0051726 regulation of cell cycle 2 25 141 18 0.6586976 hsa-mir-212 TargetScan GO:0051983 regulation of chromosome segregation 0 3 141 18 0.3382585 hsa-mir-212 TargetScan GO:0065003 macromolecular complex assembly 3 19 141 18 0.2059168 hsa-mir-212 TargetScan GO:0065004 protein-DNA complex assembly 1 6 141 18 0.1694105

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